內(nèi)質(zhì)網(wǎng)膜蛋白復(fù)合物亞單位6 (EMC6)是一種新型的胃癌抑癌因子

2017年8月，北京大學(xué)基礎(chǔ)醫(yī)學(xué)院細(xì)胞生物學(xué)與免疫學(xué)系；北京中醫(yī)藥大學(xué)中日友好醫(yī)院學(xué)院；北京望京醫(yī)院腫瘤科；中國中醫(yī)科學(xué)院(Departments of Cell Biology and Immunology, School of Basic Medical Science, Peking University, Beijing 100191；College of China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing 100029；Department of Oncology, Wangjing Hospital,China Academy of Chinese Medical Sciences, Beijing 100102, China) Yun Bai老師研究團(tuán)隊(duì)在《BMB Reports》上發(fā)表論文：

“ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer”

“內(nèi)質(zhì)網(wǎng)膜蛋白復(fù)合物亞單位6 (EMC6)是一種新型的胃癌抑癌因子”

Abstract：

The endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 human adenocarcinoma gastric cancer cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored.

摘要：

內(nèi)質(zhì)網(wǎng)(ER)膜蛋白復(fù)合物亞單位6 (EMC6)是一種新的人類自噬相關(guān)分子。在這里，我們使用組織芯片和免疫組織化學(xué)技術(shù)，報告了與正常胃粘膜相比，胃腺癌患者的腺體細(xì)胞中EMC6蛋白丟失或減少。胃癌細(xì)胞中過表達(dá)EMC6抑制細(xì)胞生長、遷移、侵襲，誘導(dǎo)細(xì)胞凋亡和細(xì)胞周期阻滯于s期。進(jìn)一步研究表明，在異種移植模型中，EMC6在BGC823人腺癌胃癌細(xì)胞中過表達(dá)可降低其致瘤性，表明EMC6具有腫瘤抑制因子的特性。這是**發(fā)現(xiàn)EMC6誘導(dǎo)胃癌細(xì)胞死亡的研究。EMC6作為腫瘤抑制因子的分子機(jī)制有待進(jìn)一步探索。

該論文中，BGC823和SGC7901細(xì)胞體外培養(yǎng)是使用Ausbian特級胎牛血清完成的。欲了解或購買Ausbian特級胎牛血清可以聯(lián)系北京締一生物400-166-8600.